Structural variation of protein conformation in three different physical states by Raman spectroscopy. Structure, function and sequence significance of disordered domain in human human proteins, molecular docking, Particular focus is on how small molecules interact with protein disorder to resist their aggregation. Focused proteins and peptides are amyloid beta, lysozyme and insulin.
Senior Research Fellow
Sandip Dolui
Diversifying role of proteins is always a matter of enigma. These proteins are expressed within cells at a precise level. If there is alternation, then there is trouble. This anomaly is common in the case of Parkinson’s disease. Here the wrongdoer is Alpha-synuclein. I am devoted to demystifying the complex behavior of Alpha-synuclein in several solution conditions by using various spectroscopic methods. Structure of amyloid species by Raman and NMR in different state of aggregation is the main focal theme of my project. Besides, these I am interested to check the toxic level of this protein oligomerstowards neuronal cells.
Senior Research Fellow
Animesh Mondal
Structural aspects of antimicrobial plant proteins particularly derived from plant tissue. Extraction, purification of thionins and analysing interaction of them with membranes and elucidating the biophysical characters of such proteins using fluorescence, Circular dichroism, Atomic Force microscopy, NMR and Raman spectroscopy. Analysis of the effect of membrane curvature on membrane bound intrinsically disordered protein conformation.
Junior Research fellow
Lopamudra Das
Nanoparticles and their conjugation with bio-molecules in green process. Intended this work relate to investigate the morphology, size and crystal diffraction pattern of gold nanoparticles and their biophysical property (such as: protein binding). Developing porphyrin based nano conjugate for cancer therapy. Synthesis of drug conjugated gold nanoparticles in significance to their application in nano-biology. Nanoparticles as a toxic metal ion sensing probe under physiological conditions.
Senior Research Fellow
Kaushik Bera
Synthesis of single & multi directional organic switching system for sensing application and their DFT study
Senior Research fellow
Krishnendu Khamaru
Studying the effects of mutation on Alpha Synuclein aggregation and their biological behavior.
Comparing the structural properties, aggregation and neurodegenerative behavior of the wild type and mutant.
Also desires to see the action of aggregation inhibitors on the mutants.
Expression and characterization of NS3 dengue protease.
Biophysical characterization of Proteins by fluorescence, NMR and Raman
Junior Research Fellow